【摘要】 目的 研究2-氯化腺苷对惊厥大鼠外周血淋巴细胞早期凋亡的影响。方法 在Wistar大鼠腹腔注射马桑内酯诱发大鼠惊厥发作，制作癫痫模型。将30只Wistar大鼠随机分为3组，A组:致痫组10只;B组:致痫+2-氯化腺苷组10只(0.6mg/kg);C组:致痫+生理盐水组10只。采用流式细胞仪观察比较A，B，C组外周血淋巴细胞早期凋亡率的变化。结果 (1)致痫后6h，12h，24h大鼠外周血淋巴细胞凋亡率低于致痫前，经统计学处理，差异均有非常显著性(P<0.01)。(2)致痫后各时间点给予2-氯化腺苷组淋巴细胞凋亡率高于致痫组及生理盐水组淋巴细胞凋亡率，经统计学处理，差异均有非常显著性(P<0.01)。结论 2-氯化腺苷诱导致痫大鼠外周血淋巴细胞凋亡。

    关键词 2-氯化腺苷 癫痫 凋亡 淋巴细胞 大鼠

    The influence of2-CAdo on early apoptotic lymphocyte in peripheral blood of convulsion rats Wu Chunyan，Zhang Aiqi，Li Jing，et al.

    Daqing Oil Field General Hospital Pediatrics163001.

    【Abstract】 Objective To explore the influence of2-CAdo on early apoptotic lymphocyte in peripheral blood of convulsion rats.Methods The epilepsy model was established by injecting coriaria lactone(CL)into Wistar rats to induce the generalized seizures.Thirty rats were randomly divided into three groups ......