SREBPs天然小分子抑制剂的药理学研究进展(7)
[45] ANDRADE JM，PARAISO AF，DE OLIVEIRA MV，et al.Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation[J]. Nutrition，2014，30(7/8)：915-919.
[46] TANG LY，CHEN Y，RUI BB，et al. Resveratrol ameliorates lipid accumulation in HepG2 cells，associated with down-regulation of lipin1 expression[J]. Can J Physiol Pharmacol，2015. DOI：10.1139/cjpp-2015-0125.
[47] YASHIRO T，NANMOKU M，SHIMIZU M，et al. Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins[J]. Atherosclerosis，2012，220(2)：369-374.
[48] SEO MS，KIM JH，KIM HJ，et al. Honokiol activates the LKB1-AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes[J]. Toxicol Appl Pharmacol，2015，284(2)：113-124.
[49] HSU WH，CHEN TH，LEE BH，et al. Monascin and ankaflavin act as natural AMPK activators with PPARalpha agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice[J]. Food Chem Toxicol，2014，64：94-103.
[50] LEE BH，HSU WH，HUANG T，et al. Monascin improves diabetes and dyslipidemia by regulating PPARγ and inhibiting lipogenesis in fructose-rich diet-induced C57BL/6 mice[J]. Food Funct，2013，4(6)：950-959.
[51] KIM MB，SONG Y，KIM C，et al. Kirenol inhibits adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3T3-L1 adipocytes[J]. Biochem Biophys Res Commun，2014，445(2)：433-438.
[52] LEHMANN JM，KLIEWER SA，MOORE LB，et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway[J]. J Biol Chem，1997，272(6)：3137-3140.
(收稿日期：2017-12-04 修回日期：2018-03-30)
(編辑：段思怡), 百拇医药(谢治深 赵振彪 张振强 王辉)
[46] TANG LY，CHEN Y，RUI BB，et al. Resveratrol ameliorates lipid accumulation in HepG2 cells，associated with down-regulation of lipin1 expression[J]. Can J Physiol Pharmacol，2015. DOI：10.1139/cjpp-2015-0125.
[47] YASHIRO T，NANMOKU M，SHIMIZU M，et al. Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins[J]. Atherosclerosis，2012，220(2)：369-374.
[48] SEO MS，KIM JH，KIM HJ，et al. Honokiol activates the LKB1-AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes[J]. Toxicol Appl Pharmacol，2015，284(2)：113-124.
[49] HSU WH，CHEN TH，LEE BH，et al. Monascin and ankaflavin act as natural AMPK activators with PPARalpha agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice[J]. Food Chem Toxicol，2014，64：94-103.
[50] LEE BH，HSU WH，HUANG T，et al. Monascin improves diabetes and dyslipidemia by regulating PPARγ and inhibiting lipogenesis in fructose-rich diet-induced C57BL/6 mice[J]. Food Funct，2013，4(6)：950-959.
[51] KIM MB，SONG Y，KIM C，et al. Kirenol inhibits adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3T3-L1 adipocytes[J]. Biochem Biophys Res Commun，2014，445(2)：433-438.
[52] LEHMANN JM，KLIEWER SA，MOORE LB，et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway[J]. J Biol Chem，1997，272(6)：3137-3140.
(收稿日期：2017-12-04 修回日期：2018-03-30)
(編辑：段思怡), 百拇医药(谢治深 赵振彪 张振强 王辉)