荜茇总生物碱对6—羟基多巴胺致帕金森病大鼠多巴胺能神经元损伤

荜茇总生物碱对6—羟基多巴胺致帕金森病大鼠多巴胺能神经元损伤的保护作用研究(5)

http://www.100md.com 2014年5月1日《中国中药杂志》 2014年第9期

     (1. School of Traditional Chinese Medicine， Capital Medical University， Beijing 100069， China；

    2. Beijing Institute of Neural Science， Capital Medical University， Beijing 100069， China)

    [Abstract] Objective： To discuss the protective effect of alkaloids from Piper longum(PLA) in rat dopaminergic neuron injury of 6-OHDA-induced Parkinson′s disease and its possible mechanism. Method： The rat PD model was established by injecting 6-OHDA into the unilateral striatum with a brain solid positioner. The PD rats were divided into the PLA group (50 mg·kg^{-1^{·d^{-1^{) ......
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