氨茶碱联合甲基强的松龙治疗支气管哮喘的临床观察(1)
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[摘要] 目的：探讨静脉滴注氨茶碱联合甲基强的松龙和静脉滴注氨茶碱治疗支气管哮喘的疗效。方法：回顾性分析本院2008年2月～2010年2月收治入院的130例轻、中度支气管哮喘患者，随机分为两组。观察组65例，应用氨茶碱0.25 g加入5%葡萄糖注射液250 ml静滴，每日1次，甲基强的松龙40 mg加入5%葡萄糖注射液100 ml静滴，每日2次；对照组65例，应用氨茶碱0.25 g加入5%葡萄糖注射液250 ml静滴，每日1次。结果：本研究中采用氨茶碱联合甲基强的松龙治疗支气管哮喘其总有效率为89.23%，对照组总有效率为70.77%，两组疗效比较，差异有统计学意义，P<0.05；两组患者经治疗后临床症状均有所改善，观察组明显优于对照组，差异有统计学意义(P<0.05)。结论：静脉滴注氨茶碱加甲基强的松龙治疗支气管哮喘急性期疗效显著，是有效的治疗方法之一。
[关键词] 甲基强的松龙；氨茶碱；支气管哮喘；药物治疗；不良反应
[中图分类号] R974 [文献标识码] B [文章编号] 1674-4721(2011)11(c)-066-02
Clinical observation of aminophylline and methylprednisolone combined treatment of bronchial asthma
WANG Chunfang, QIAO Ming
Department of Respiratory, the Third People's Hospital of Datong City in Shanxi Province, Datong 037008, China
[Abstract] Objective: To investigate the clinical effect of combined intravenous infusion of aminophylline and methylprednisolone intravenous aminophylline in the treatment of bronchial asthma. Methods: A retrospective analysis of our hospital in February 2008 to February 2010 was admitted to hospital and 130 patients with mild to moderate asthma were randomly divided into two groups. Observation group of 65 patients, application of aminophylline 0.25 g 5% glucose injection 250 ml infusion, day 1, 40 mg methylprednisolone injection in 5% glucose infusion 100 ml, 2 times a day; the control group 65 cases, application of aminophylline 0.25 g 5% glucose injection 250 ml infusion, day 1. Results: The total effective rate of observation group was 70.77%, difference between the two groups was significant, P<0.05; two groups of patients after treatment, clinical symptoms after treatment were improved. Observation group was better than the control group, and there was significant difference (P<0.05). Conclusion: Intravenous infusion of aminophylline plus methylprednisolone in the treatment of bronchial asthma acute phase effect is significant, is an effective treatment method.
[Key words] Methylprednisolone; Aminophylline; Bronchial asthma; Drug therapy; Adverse reactions ......
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