米索前列醇直肠用药联合缩宫素对剖宫产术后出血的预防效果(1)
[摘要]目的 探讨米索前列醇直肠用药联合缩宫素对剖宫产术后出血的预防效果。方法 选取2018年1～6月于我院行剖宫产手术的80例产妇作为研究对象，随机分为对照组和观察组，每组各40例。两组产妇均在胎儿娩出后立即给药，对照组产妇接受宫体注射缩宫素，观察组产妇在胎儿娩出后除宫体注射缩宫素给予肛塞米索前列醇治疗。观察并比较两组产妇术中及产后24 h的出血量，产前、产后血红蛋白水平及不良反应发生情况。结果 两组产妇术中及术后24 h出血量比较，差异无统计学意义(P>0.05)。两组产妇产前和产后血红蛋白水平比较，差异无统计学意义(P>0.05)。两组产妇均无不良反应发生。结论 直肠用米索前列醇片联合缩宫素与单纯使用缩宫素对预防产后出血没有差异，临床应根据具体情况选择用药。
[关键词]米索前列醇;直肠;缩宫素;产后出血;剖宫产术
[中图分类号] R719 [文献标识码] A [文章编号] 1674-4721(2019)2(c)-0105-03
[Abstract] Objective To explore the preventive effect of Misoprostol rectal medication combined with Oxytocin on hemorrhage after cesarean section. Methods Eighty parturients who underwent caesarean section in our hospital from January to June 2018 were randomly divided into control group and observation group， with 40 cases in each group. Both groups were given Oxytocin immediately after the delivery of the fetus， the control group received Oxytocin injection into the uterus， the observation group was given anal misoprostol after the delivery of the fetus. Observe and compare the amount of bleeding during and 24 hours after delivery， the level of hemoglobin before and after delivery and the occurrence of adverse reactions between the two groups. Results There was no significant difference in the amount of bleeding during operation and 24 hours after operation between the two groups (P>0.05). There was no significant difference in prenatal and postpartum hemoglobin levels between the two groups (P>0.05). There were no adverse reactions in both groups. Conclusion There is no difference between rectal Misoprostol Tablets combined with Oxytocin and simple use of Oxytocin in preventing postpartum hemorrhage.
[Key words] Misoprostol; Rectum; Oxytocin; Postpartum hemorrhage; Cesarean section
剖宫产术是产科领域中的重要手术，是经腹切开子宫取出胎儿的方式，临床上常用来挽救产妇和胎儿的生命安全。产后出血是产科常见并发症，是产妇死亡的主要原因之一，其致死因素居全国首位。如何有效地防治产后出血的发生，降低产后出血率，预防和控制产后出血导致的死亡成为临床医生关注的首要问题[1-2]。临床为预防产后出血做了大量探索，20世纪30年代英国发现了具有缩宫作用的缩宫素，并于50年代实现人工合成。多年来该药被用于促进分娩和预防产后大出血[3]。缩宫素的应用取得了较好效果，但不同个体对缩宫素的敏感性不同。有资料显示，采用米索前列醇預防止血，能有效减少产程耗时，降低产后出血量[4]。本研究利用我院病例资源，探讨在应用缩宫素的基础上加用直肠给药米索前列醇片对产妇产后出血的预防作用，现报道如下。
1资料与方法
1.1一般资料
选取2018年1～6月于我院行剖宫产手术的80例产妇作为研究对象，随机分为对照组和观察组，每组各40例。对照组中，平均年龄(30.95±5.55)岁;平均身高(1.57±0.05)m;平均体重(66.47±8.10)kg;平均孕龄(38.35±1.43)周。观察组中，平均年龄(31±5.29)岁;平均身高(1.56±0.04)m;平均体重(66.64±9.0)kg;平均孕龄(38.16±1.28)周。两组产妇的一般资料比较，差异无统计学意义(P>0.05)，具有可比性。所有产妇及其家属同意手术并签署知情同意书。本研究已经医院医学伦理委员会审核批准。, 百拇医药(彭燕琼 彭石健)
[关键词]米索前列醇;直肠;缩宫素;产后出血;剖宫产术
[中图分类号] R719 [文献标识码] A [文章编号] 1674-4721(2019)2(c)-0105-03
[Abstract] Objective To explore the preventive effect of Misoprostol rectal medication combined with Oxytocin on hemorrhage after cesarean section. Methods Eighty parturients who underwent caesarean section in our hospital from January to June 2018 were randomly divided into control group and observation group， with 40 cases in each group. Both groups were given Oxytocin immediately after the delivery of the fetus， the control group received Oxytocin injection into the uterus， the observation group was given anal misoprostol after the delivery of the fetus. Observe and compare the amount of bleeding during and 24 hours after delivery， the level of hemoglobin before and after delivery and the occurrence of adverse reactions between the two groups. Results There was no significant difference in the amount of bleeding during operation and 24 hours after operation between the two groups (P>0.05). There was no significant difference in prenatal and postpartum hemoglobin levels between the two groups (P>0.05). There were no adverse reactions in both groups. Conclusion There is no difference between rectal Misoprostol Tablets combined with Oxytocin and simple use of Oxytocin in preventing postpartum hemorrhage.
[Key words] Misoprostol; Rectum; Oxytocin; Postpartum hemorrhage; Cesarean section
剖宫产术是产科领域中的重要手术，是经腹切开子宫取出胎儿的方式，临床上常用来挽救产妇和胎儿的生命安全。产后出血是产科常见并发症，是产妇死亡的主要原因之一，其致死因素居全国首位。如何有效地防治产后出血的发生，降低产后出血率，预防和控制产后出血导致的死亡成为临床医生关注的首要问题[1-2]。临床为预防产后出血做了大量探索，20世纪30年代英国发现了具有缩宫作用的缩宫素，并于50年代实现人工合成。多年来该药被用于促进分娩和预防产后大出血[3]。缩宫素的应用取得了较好效果，但不同个体对缩宫素的敏感性不同。有资料显示，采用米索前列醇預防止血，能有效减少产程耗时，降低产后出血量[4]。本研究利用我院病例资源，探讨在应用缩宫素的基础上加用直肠给药米索前列醇片对产妇产后出血的预防作用，现报道如下。
1资料与方法
1.1一般资料
选取2018年1～6月于我院行剖宫产手术的80例产妇作为研究对象，随机分为对照组和观察组，每组各40例。对照组中，平均年龄(30.95±5.55)岁;平均身高(1.57±0.05)m;平均体重(66.47±8.10)kg;平均孕龄(38.35±1.43)周。观察组中，平均年龄(31±5.29)岁;平均身高(1.56±0.04)m;平均体重(66.64±9.0)kg;平均孕龄(38.16±1.28)周。两组产妇的一般资料比较，差异无统计学意义(P>0.05)，具有可比性。所有产妇及其家属同意手术并签署知情同意书。本研究已经医院医学伦理委员会审核批准。, 百拇医药(彭燕琼 彭石健)