硝酸甘油联合利尿合剂治疗难治性心力衰竭的临床效果(1)
[摘要]目的 探討硝酸甘油联合利尿合剂对难治性心力衰竭的临床治疗效果。方法 选取2016年6月～2018年5月我院收治的48例难治性心力衰竭患者作为研究对象，按照随机数字表法分为对照组与试验组，各24例。在相同常规对症治疗基础上，对照组采取硝酸甘油治疗，试验组采取硝酸甘油联合利尿合剂治疗。比较两组患者的治疗有效率、心力衰竭改善情况以及不良反应情况。结果 实验组的治疗总有效率为91.67%，高于对照组的66.67%，差异有统计学意义(P<0.05)。两组治疗前的B型脑钠肽(BNP)浓度、左心室射血分数比较，差异无统计学意义(P>0.05)。两组治疗后的BNP浓度低于治疗前，差异有统计学意义(P<0.05)。两组治疗后的左心室射血分数高于治疗前，差异有统计学意义(P<0.05)。实验组治疗后的BNP浓度低于对照组，差异有统计学意义(P<0.05)。实验组治疗后的左心室射血分数高于对照组，差异有统计学意义(P<0.05)。两组的不良反应总发生率比较，差异无统计学意义(P>0.05)。结论 在难治性心力衰竭的临床治疗中，采取硝酸甘油联合利尿合剂治疗，可以显著提高治疗效果，降低患者BNP浓度，提升患者左心室射血分数，且不会增加不良反应发生率，能够改善患者生存质量，具有极大的推广应用价值。
[关键词]硝酸甘油；利尿合剂；难治性心力衰竭；疗效
[中图分类号] R541.6 [文献标识码] A [文章编号] 1674-4721(2019)4(a)-0046-04
[Abstract] Objective To investigate the clinical effect of Nitroglycerin combined with diuretic mixture on refractory heart failure (HF). Methods A total of 48 patients with refractory HF admitted to our hospital from June 2016 to May 2018 were enrolled as study subjects. The participants were divided into the control group and the experimental group according to the random number table method， 24 cases in each group. On the basis of the same routine symptomatic treatment， the control group was treated with Nitroglycerin， while in the experimental group， patients were treated with Nitroglycerin combined with diuretic mixture. The therapeutic effectiveness rate， improvement of HF， and adverse reactions were compared between the two groups. Results The total effectiveness rate of the experimental group was 91.67%， which was higher than that of the control group accounting for 66.67%， with statistical difference (P<0.05). There was no significant difference in brain natriuretic peptide (BNP) concentration and left ventricular ejection fraction (LVEF) between the two groups before treatment (P>0.05). The BNP concentration after treatment was lower than that before treatment in both groups， with statistical significance (P<0.05). The LVEF after treatment was higher than that before treatment in both groups， with statistical significance (P<0.05). The BNP concentration in the experimental group after treatment was lower than that in the control group， with statistical significance (P<0.05). The LVEF in the experimental group after treatment was higher than that in the control group， with significant difference (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion In the clinical treatment of refractory HF， application of Nitroglycerin combined with diuretic mixture can remarkably improve the therapeutic effect， reduce the concentration of BNP in patients， and enhance patient′s LVEF without increasing the adverse reaction rate， and can ameliorate the quality of life， which has a great promotion value., 百拇医药(许旭茂)
[关键词]硝酸甘油；利尿合剂；难治性心力衰竭；疗效
[中图分类号] R541.6 [文献标识码] A [文章编号] 1674-4721(2019)4(a)-0046-04
[Abstract] Objective To investigate the clinical effect of Nitroglycerin combined with diuretic mixture on refractory heart failure (HF). Methods A total of 48 patients with refractory HF admitted to our hospital from June 2016 to May 2018 were enrolled as study subjects. The participants were divided into the control group and the experimental group according to the random number table method， 24 cases in each group. On the basis of the same routine symptomatic treatment， the control group was treated with Nitroglycerin， while in the experimental group， patients were treated with Nitroglycerin combined with diuretic mixture. The therapeutic effectiveness rate， improvement of HF， and adverse reactions were compared between the two groups. Results The total effectiveness rate of the experimental group was 91.67%， which was higher than that of the control group accounting for 66.67%， with statistical difference (P<0.05). There was no significant difference in brain natriuretic peptide (BNP) concentration and left ventricular ejection fraction (LVEF) between the two groups before treatment (P>0.05). The BNP concentration after treatment was lower than that before treatment in both groups， with statistical significance (P<0.05). The LVEF after treatment was higher than that before treatment in both groups， with statistical significance (P<0.05). The BNP concentration in the experimental group after treatment was lower than that in the control group， with statistical significance (P<0.05). The LVEF in the experimental group after treatment was higher than that in the control group， with significant difference (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion In the clinical treatment of refractory HF， application of Nitroglycerin combined with diuretic mixture can remarkably improve the therapeutic effect， reduce the concentration of BNP in patients， and enhance patient′s LVEF without increasing the adverse reaction rate， and can ameliorate the quality of life， which has a great promotion value., 百拇医药(许旭茂)