[摘要] 目的 探讨2型糖尿病口服药治疗效果欠佳的患者改用餐前门冬胰岛素联合睡前甘精胰岛素治疗的临床效果。 方法 选择71例口服药治疗效果欠佳的2型糖尿病患者进行研究，患者采用餐前皮下注射门冬胰岛素联合睡前皮下注射甘精胰岛素治疗，比较治疗前后患者血糖控制情况及胰岛C肽释放功能。 结果 71例患者治疗后血糖较治疗前显著下降，空腹、糖负荷后1、2、3h后C-P值显著高于治疗前(P<0.05)。 结论 口服降糖药效果欠佳的2型糖尿病患者采用餐前皮下注射门冬胰岛素联合睡前皮下注射甘精胰岛素治疗，可显著改善患者血糖控制程度，改善胰岛C肽释放功能。

    [关键词] 2型糖尿病；甘精胰岛素；胰岛C肽；降糖药物；胰岛β细胞

    [中图分类号] R587.1 [文献标识码] B [文章编号] 2095-0616(2015)15-85-03

    [Abstract] Objective To discuss clinical efficacy of fasting Insulin aspart combined with bedtime glargine for type 2 diabetes patients with poor oral treatment. Methods 71 type 2 diabetes patients with poor oral treatment were selected as subjects. All patients were treated with fasting Insulin aspart combined with bedtime glargine. Glycemic control and insulin C-peptide release function were compared before and after treatment. Results After treatment ......